A novel statistical method predicts mutability of the genomic segments of the SARS-CoV-2 virusResearch Article Published on 2022-12-132022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] affected antiviral drugs approach candidate coding regions codon conserved correlated correlation determine develop disease distribution effective epitope Frequency genomic identify immunogenic peptide large-scale analysis mutability offer overcome pandemic pathogenesis of SARS-CoV-2 predict predicted Protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 scientist sequence Seven spike glycoprotein statistical statistical analysis target the SARS-CoV-2 virus treatments for COVID-19 Vaccine viral genome viral mutation whole genome whole genome sequence Word Ranking [DOI] 10.1017/qrd.2021.13 PMC 바로가기 [Article Type] Research Article
Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] antibodies antibody Antigen association Asymptomatic asymptomatic individual asymptomatic infection betacoronavirus Betacoronavirus Community convalescent correlated COVID-19 COVID-19 severity develop diagnosed diagnostics disease severity domains Epitopes Evidence evidence of finding FIVE five groups HKU1 Hospitalization IgG IgGs Immunity immunogenic immunogenic peptide individual Infection less MERS-CoV nucleocapsid protein Nucleocapsid proteins OC43 participant pathogenic pathogenic mechanisms peptide peptide array peptides pilot study predicted Protein RBDs reaction Receptor binding domain Region repertoire SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted Seroprevalence seroprevalence. severity severity of COVID-19 symptomatic symptomatic COVID-19 symptomatic infection therapeutic therapeutic antibodies Vaccines Viral with COVID-19 without symptoms [DOI] 10.1080/21505594.2022.2073025 PMC 바로가기 [Article Type] Article
Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction감산 단백질체학 보조 치료 표적 마이닝 및 면역 반응 유도를 위한 Candida auris에 대한 앙상블 백신 설계Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] antigenic approach approach B cell Candida Candida auris candidate caused characterization Co-infection COVID-19 COVID-19 patient CTL demonstrated effective effective therapy Efficacy feature global pandemic HTL IgG IgM IL-6 immune immune response Immune simulation immunogenic peptide in-silico Infection infections interferon Interferon-α molecular docking Multi-epitope vaccine non-allergenic peptides producing proteome proteomics provide SARS-CoV-2 Seven Subtractive proteomics target targets the vaccine therapeutic target therapeutic targets threshold Vaccine vaccine candidate vaccine candidates Vaccines. validation variant variants was performed [DOI] 10.1016/j.compbiomed.2022.105462 PMC 바로가기 [Article Type] Article
Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigensCD8+ T 세포 병원성 에피토프 및 암 신생항원 예측에서 기존 컴퓨터 모델의 성능 평가Article Published on 2022-05-132022-09-12 Journal: Briefings in Bioinformatics [Category] MERS, 진단, [키워드] acute respiratory syndrome binding affinity Cancer cancer neoantigen cancers CD8 T-cell CD8 T-cell target CD8+ T cell coronavirus disease distribution epitope evaluated Evaluating Evidence facilitate Factor feature highlight histocompatibility complex HLA ligand immunogenic immunogenic peptide immunotherapies Immunotherapy Intensive long-term immune responses malignant cell modulate offer parameter pathogen pathogenic pathology peptide peptide immunogenicity peptide presentation. peptides predictors question random Research robust stability suggested T cell T cell receptor T-cell T-cell Response target threshold training data Vaccine Variation virus [DOI] 10.1093/bib/bbac141 PMC 바로가기 [Article Type] Article
Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters Research Published on 2022-04-262022-10-05 Journal: NPJ Vaccines [Category] 유전자 메커니즘, [키워드] BALB/c C57BL/6 demonstrated DNA plasmid DNA vaccine effective evaluated expressing hamster hamsters Health immunized immunogenic peptide Infection Infectious virus lung mice morbidity and mortality neutralizing antibody pathology PROTECT reduce reducing robust SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant severe disease spike gene the SARS-CoV-2 vaccination Vaccine Vaccines viral burden was reduced weight loss [DOI] 10.1038/s41541-022-00461-5 [Article Type] Research
DeepImmuno: deep learning-empowered prediction and generation of immunogenic peptides for T-cell immunityDeepimmuno : T- 세포 면역을위한 면역 원성 펩티드의 딥 러닝에 대한 예측 및 생성Problem Solving Protocol Published on 2021-11-032022-09-10 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 변종, [키워드] AdaBoost adaptive immune system addition Algorithms alleles Antigen antigen recognition antigens approach best binding Cancer Cancer immunotherapy Cell chose CNN computational method Computational methods conducted Convolutional neural network COVID-19 dataset datasets deep learning Dengue dengue virus distribution elicit FIVE foreign antigen foreign antigens forest GAN generative adversarial network human leukocyte antigen immunogenic peptide immunogenic potential immunogenicity Impact independent killing lack leukocyte life-threatening neoantigen Pathogens peptide peptides Physicochemical properties physicochemical property predict Random forest residual residue SARS-CoV-2 SARS-CoV-2 variants seeking sequence source code Support support vector machine T-cell T-cell immunity T-cell Response T-cells targeted therapy Vaccine [DOI] 10.1093/bib/bbab160 PMC 바로가기 [Article Type] Problem Solving Protocol
The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use인간 사용을 위한 DNA 유전자형 Aotus 원숭이에서 최초의 화학적으로 합성되고 면역원성이 높은 항-SARS-CoV-2 펩티드Immunology Published on 2021-09-032022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] analysed antibody antigenicity association Coverage COVID-19 DNA ELISA titre for inclusion highlight HLA alleles HLA-DRβ1*/Aona-DRβ host cell Human humans IFA immune protection immune response immunogenic immunogenic peptide immunological Infection long-lasting membrane MHC class MHCII MHCII-peptide-TCR complex Mild modified synthetic peptide Monkey neutralising antibody parental Patient peptide peptides Population PPIIL-propensity predicted producing Protein SARS-CoV-2 SARS-CoV-2 neutralising antibody SARS-CoV-2 spike selected serum sample severe SARS-CoV-2 Structural analysis suggested were used [DOI] 10.3389/fimmu.2021.724060 PMC 바로가기 [Article Type] Immunology
Longitudinal and proteome-wide analyses of antibodies in COVID-19 patients reveal features of the humoral immune response to SARS-CoV-2COVID-19 환자의 항체에 대한 종단 및 프로테옴 전체 분석은 SARS-CoV-2에 대한 체액성 면역 반응의 특징을 보여줍니다Article Published on 2021-07-272022-09-11 Journal: Journal of advanced research [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V1 501Y.V2 amino acids Analysis analysis antibodies antibody assays B-cell B.1.1.7 B.1.351 B.1.617 Brazil country COVID-19 COVID-19 patient COVID-19 patients develop dominant epitope effective Epidemic epitope Epitopes feature FIVE global health Health humoral immune response IgA IgG IgM immune Immune escape immune response immune responses immune system immunogenic peptide India Infection information Intensive key amino acid lead linear longitudinal measure mild patients morbidity morbidity and mortality Neutralization assay Neutralizing antibodies new SARS-CoV-2 non-structural proteins peptides performed proteomics resource respond Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2. severe and mild patients South Africa Spread Treatment Vaccine Vaccine design variant variants Viral viral infection [DOI] 10.1016/j.jare.2021.07.008 PMC 바로가기 [Article Type] Article
Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell ImmunityCellular Response to Infection Published on 2020-12-212022-10-30 Journal: Journal of Virology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Analysis assays Assessing binding candidate CD8 Cellular immune response cellular response circulating conserved contribute Convalescent patients coronavirus coronavirus immunity Coverage COVID-19 vaccines Critical cross-reactivity Developing diagnostic tools disease effective Efficacy effort elicit elicited epitope exhibited highly networked/conserved T-cell epitope derived peptides HLA allele homology human coronavirus human coronaviruses identification identify Immunity immunogen immunogenic peptide immunoinformatics in silico novel coronavirus disease nucleocapsid nucleocapsid and spike proteins peptide Protein protein network Region response resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific immune response SARS-CoV-2-specific T-cell responses spike Spike proteins survivor T cell T-cell T-cell effector/polyfunctionality T-cell epitope T-cell immunity T-cell Response the SARS-CoV-2 to define Vaccine vaccine candidates variant Viral proteins viral variant [DOI] 10.1128/JVI.02002-20 PMC 바로가기 [Article Type] Cellular Response to Infection
In silico identification of vaccine targets for 2019-nCoVResearch Article Published on 2020-04-142022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019-nCoV accelerate Adaptive immunity Algorithm aligned binding can be used candidate characterized China Chinese conducted coronavirus curated database de novo death develop European population experimental validation Health HLA allele IEDB Immune Epitope Database immunogenic immunogenic peptide immunogenicity in silico nCoV NetMHCpan peptide peptides predicted Predictive model proteome provide resource SARS CoV second similarity T cell assays T cell cross-reactivity target TCR Treatment Vaccine Vaccine development [DOI] 10.12688/f1000research.22507.2 PMC 바로가기 [Article Type] Research Article